熊本大学　微生物学分野

1. Goto T, Ogura Y, Hirakawa H, Tomida J, Morita Y, Akaike T, Hayashi T, and Kawamura Y.
   Complete genome sequence of Helicobacter cinaedi strain PAGU611, isolated in a case of human bacteremia.
   J Bacteriol. in press (2012).
2. Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M.
   S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents.
   J Pharm Sci. in press (2012).
3. Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S, Sawa T, Takeya M, Ogawa H, Yamabe H, and Akaike T.
   Potential association of Helicobacter cinaedi with atrial arrhythmia and　atherosclerosis.
   Microbiol Immunol. 56:145-154 (2012).
4. Ahmed KA, Sawa T, Ihara H, Kasamatsu S, Yoshitake J, Okamoto T, Fujii S, and Akaike T.
   Regulation by mitochondrial superoxide and NADPH oxidase of cell formation of nitrated cyclic GMP: potential implications for ROS signaling.
   Biochem J. 441:719-730 (2012).
5. Sawa T and Akaike T.
   Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment.
   In Novel Therapeutic Concepts in Targeting Glioma (eds., Faris Farassati), InTech (Open Access Company), p. 247-262 (2012).
6. 赤池孝章
   基礎の基礎
   細胞工学.　特集「活性酸素シグナル制御とレドックスホメオスタシス」監修：赤池孝章. 31(2):134-137 (2012).
7. 西田基宏, 澤智裕.
   心不全におけるGタンパク質の酸化修飾と活性酸素・新電子シグナル制御
   細胞工学　特集「活性酸素シグナル制御とレドックスホメオスタシス」監修：赤池孝章. 31(2):150-154 (2012).
8. 藤井重元, 赤池孝章.
   ニトロ化環状ヌクレオチドによるタンパク質S−グアニル化を介する酸化ストレス適応応答の分子機序
   生化学. 84(2):124-128 (2012).

1. Akaike T, van der Vliet A, and Eaton P.
   Frontiers in nitric oxide and redox signaling.
   Nitric Oxide 25: 57-58 (2011).
2. Ihara H, Ahmed KA, Ida T, Kasamatsu S, Kunieda K, Okamoto T, Sawa T, and Akaike T.
   Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3',5'-cyclic monophosphate formed in glia cells.
   Nitric Oxide 25: 169-175 (2011).
3. Ihara H, Sawa T, Nakabeppu Y, and Akaike T.
   Nucleotides function as endogenous chemical sensors for oxidative stress signaling.
   J Clin Biochem Nutr. 48: 1-7 (2011).
4. Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T, Shudo K, and Katsuki H.
   Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF.
   J Neurochem. 116: 323-333 (2011).
5. Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Hisato F, Nako H, Toyama K, Dong YF, Ahmed KA, Sawa T, Akaike T, and Kim-Mitsuyama S.
   Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice.
   Br J Pharmacol. 162: 1884-1893 (2011).
6. Ahmed KA, Sawa T, and Akaike T.
   Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides.
   Amino Acids. 41: 123-130 (2011).
7. Sawa T, Ihara H, and Akaike T.
   Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile.
   Curr Top Med Chem. 11: 1854-1860 (2011).
8. Yoshida E, Toyama T, Shinkai Y, Sawa T, Akaike T, Kumagai Y.
   Detoxification of methylmercury by hydrogen sulfide-producing enzyme in mammalian cells.
   Chem. Res. Toxicol. 24: 1633-1635 (2011)
9. Ishima Y, Yoshida F, Kragh-Hansen U, Watanabe K, Katayama N, Nakajou K, Akaike T, Kai T, Maruyama T, and Otagiri M.
   Cellular uptake mechanisms and responses to NO transferred from mono-and poly-S-nitrosated human serum albumin.
   Free Radic Res. 45: 1196-1206 (2011).
   
   
10. 澤 智裕，小野勝彦，赤池孝章.
    活性酸素・一酸化窒素によるニトロ化シグナルと抗炎症作用.
    感染・炎症・免疫. 41: 12-19 (2011).
    
11. 今吉理恵子, 岡本竜哉, 永尾潤一, 長環, 松永勝政, 赤池孝章, 上西秀則.
    植物精油citralのインフルエンザウイルス感染能抑制効果について.
    医学と生物学. 155: 489-494 (2011).
12. 岡本竜哉, 居原秀, 赤池孝章.
    喫煙と酸化ストレス: Oxidative stress induced by cigarette smoking.
    最新精神医学. 特集号「精神障害者と喫煙」16: 431-439 (2011).
13. 澤 智裕, 赤池孝章.
    一酸化窒素 nitric oxide/NO.
    免疫の事典（桂 義元, 河本 宏, 小安重夫, 山本一彦 編）.　朝倉書店, p. 39 (2011).
14. 澤 智裕, 赤池孝章.
    活性酸素 reactive oxygen species (ROS).
    免疫の事典（桂 義元, 河本 宏, 小安重夫, 山本一彦 編）.　朝倉書店, p. 109 (2011).

1. Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahmed KA, Ishima Y, Motohashi H, Yamamoto M, and Akaike T.
   The critical role of nitric oxide signaling, via proteinS-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response.
   J Biol Chem. 285: 23970-23984 (2010).
2. Okamoto T, Khan S, Oyama K, Fujii S, Sawa T, and Akaike T.
   A new paradigm for antimicrobial host defense mediated by a nitrated cyclic nucleotide.
   J Clin Biochem Nutr. 46: 14-19 (2010).
3. Sawa T, Arimoto H, and Akaike T.
   Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles.
   Bioconjugate Chem. 21: 1121-1129 (2010).
4. Akaike T, Fujii S, Sawa T, and Ihara H.
   Cell signaling mediated by nitrated cyclic guanine nucleotide.
   Nitric Oxide. 23: 166-174 (2010).
   
5. Ishima Y, Hiroyama S, Kragh-Hansen U, Maruyama T, Sawa T, Akaike T, Kai T and Otagiri M.
   One-step preparation of S-nitrosated human serum albumin with high biological activities.
   Nitric Oxide. 23: 121-127 (2010).
   
6. Okamoto T, Zaki MH, Fujii S, Sawa T, and Akaike T.
   Nitric oxide-mediated host immune response and microbial pathogenesis.
   Nitric Oxide Synthase Inhibitors: From Animal Studies to Clinical Implications (Tunctan B, editor).(2010) in press.
7. 藤井重元, 澤 智裕, 赤池孝章.
   8-Nitro-cGMPの発見と生理機能の解明．
   化学と生物．48: 22-27 (2010).
8. 澤 智裕, 赤池孝章．
   毒性説から脱した活性酸素研究 —シグナル分子としての活躍—．
   現代化学．469: 34-38 (2010)．
9. 岡本竜哉, 澤 智裕, 赤池孝章．
   Nitric oxide（NO）およびNO関連物質．
   日本臨床 増刊号「広範囲血液・尿化学検査, 免疫学的検査-4」．982: 839-842 (2010)．
10. 岡本竜哉, 赤池孝章．
    呼吸器疾患における酸化ストレスと制御シグナルの分子基盤: Molecular mechanisms of nitric oxide- and reactive oxygen species-mediated signalings in the respiratory diseases．
    呼吸．29: 859-866 (2010).
11. 河村好章, 赤池孝章．
    新興感染症原因菌ーHelicobacter cinaedi．
    日本医事新報．4514: 59-62 (2010).

1. Zaki MH, Fujii S, Okamoto T, Islam S, Khan S, Ahmed KA, Sawa T, and Akaike T.
   Cytoprotective function of heme oxygenase-1 induced by a nitrated cyclic nucleotide formed during murine salmonellosis.
   J Immnol. 182: 3746-3756 (2009) .
2. 赤池孝章, 岡本竜哉, Zaki MH, 藤井重元, 澤 智裕.
   NO による細胞内感染防御の新しい展開 - New paradigm of host defense against intracellular pathogens by nitric oxide.
   Nihon Hansenbyo Gakkai Zasshi. 78: 41-47 (2009).
3. 岡本竜哉, 澤 智裕, 藤井重元, 赤池孝章.
   活性酸素・NO による感染防御シグナルの新展開 - Antimicrobial signaling mediated by reactive oxygen species and NO.
   細胞. 41: 51-55 (2009).
4. 赤池孝章．
   活性酸素のシグナル伝達機能—その生理機能の再発見と酸化ストレス研究の新展開．
   実験医学増刊：病態解明に迫る活性酸素シグナルと酸化ストレス（谷口直之監修、赤池孝章、鈴木敬一郎、内田浩二編集）pp. 2320-2329 (2009).
5. 澤 智裕, 有本博一, 赤池孝章．
   チオール基の修飾による活性酸素のセンサー機能制御．
   実験医学増刊：病態解明に迫る活性酸素シグナルと酸化ストレス（谷口直之監修、赤池孝章、鈴木敬一郎、内田浩二編集）pp. 2341-2347 (2009).

1. Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Suenaga A, Maruyama T, and Otagiri M.
   S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding.
   J Biol Chem. 283: 34966-34975 (2008).
2. Saito Y, Taguchi H, Fujii S, Sawa T, Kida E, Kabuto C, Akaike T, and Arimoto H.
   8-Nitroguanosines as chemical probes of the proteinS-guanylation.
   Chem Commun. 5984-5986 (2008).
   
3. McCarthy SM, Bove PF, Matthews DE, Akaike T, and van der Vliet A.
   Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch.
   Biochemistry. 47: 5832-5840 (2008).
   
4. Yoshitake J, Kato K, Yoshioka D, Sueishi Y, Sawa T, Akaike T, and Yoshimura T.
   Suppression of NO production and 8-nitroguanosine formation by phenol-containing endocrine-disrupting chemicals in LPS-stimulated macrophages: Involvement of estrogen receptor-dependent or -independent pathways.
   Nitric Oxide. 18: 223-228 (2008).
5. Urano T, Ito Y, Akao M, Sawa T, Miyata K, Tabata M, Morisada T, Hato T, Yano M, Kadomatsu T, Yasunaga K, Shibata R, Murohara T, Akaike T, Tanihara H, Suda T, and Oike Y.
   Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model.
   Arterioscler Thromb Vasc Biol. 28: 827-834 (2008).
6. Alam MS, Zaki MH, Sawa T, Islam S, Ahmed KA, Fujii S, Okamoto T, and Akaike T.
   Nitric oxide produced in Peyer's patches exhibits antiapoptotic activity contributing to an antimicrobial effect in murine salmonellosis.
   Microbiol Immunol. 52: 197-208 (2008).
7. Iwashita H, Fujii S, Kawamura Y, Okamoto T, Sawa T, Masaki T, Nishizono A, Higashi S, Kitamura T, Tamura F, Sasaki Y, and Akaike T.
   Identification of the Major Antigenic Protein of Helicobacter cinaedi and the Immunogenicity During Infections in Humans.
   Clin Vaccine Immunol. 15: 513-521 (2008).
   
8. Kaneko K, Akuta T, Sawa T, Kim HW, Fujii S, Okamoto T, Nakayama H, Ohigashi H, Murakami A, and Akaike T.
   Mutagenicity of 8-nitroguanosine, a product of nitrative nucleoside modification by reactive nitrogen oxides, in mammalian cells.
   Cancer Lett. 262: 239-247 (2008).
   
9. 岡本竜哉, 赤池孝章
   肺の感染炎症病態におけるニトロ化ストレスとそのバイオマーカー.
   医学のあゆみ. 224: 851-856 (2008).
10. 澤 智裕, 赤池孝章
    活性酸素を消去する物質8-ニトロcGMP．
    検査と技術. 36: 678-679 (2008).
11. 澤 智裕, 赤池孝章
    一酸化窒素（NO）とシグナル伝達．酸化ストレスの医学.
    診断と治療社（吉川敏一 監修）pp. 138-146 (2008).
12. 岡本竜哉, 藤井重元, 澤 智裕, 赤池孝章.
    感染病態における NO・活性酸素のシグナル伝達機能：酸化ストレスとその適応応答の分子メカニズム.
    Allergy From the Nose to the Lung. 6: 12-17 (2008).
13. 岡本竜哉, 赤池孝章
    教室紹介．
    ウイルス. 58: 229-231 (2008).
14. 赤池孝章, 澤 智裕
    放射線・酸化ストレスにおけるNO・活性酸素シグナル制御．
    長崎医学会雑誌（原爆特集号別冊）．83:195-199 (2008)．

1. Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi Y, Kim-Mitsuyama S, Ihara H, Kobayashi A, Yamamoto M, Fujii S, Arimoto H, and Akaike T.
   Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
   Nature Chem Biol. 3: 727-735 (2007).
2. Kitamura T, Kawamura Y, Ohkusu K, Masaki T, Iwashita H, Sawa T, Fujii S, Okamoto T, and Akaike T.
   Helicobacter cinaedi cellulitis and bacteremia in immunocompetent hosts after orthopedic surgery.
   J Clin Microbiol. 45: 31-38 (2007).
3. Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Maruyama T, Kai T, and Otagiri M.
   Effect of Endogenous ligands on the biological role of human serum albumin in S-nitrosylation.
   Biochem Biophys Res Commun. 364: 790-795 (2007).
4. Ishima Y, Sawa T, Kragh-Hansen U, Miyamoto Y, Matsushita S, Akaike T, and Otagiri M.
   S-Nitrosylation of human variant albumin Liprizzi (R410C) confers potent antibacterial and cytoprotective properties.
   J Pharmacol Exp Ther. 320: 969-977 (2007).
5. Zaki MH, Okamoto T, Sawa T, Fujii S, and Akaike T.
   Nitrative stress in respiratory inflammation caused by influenza virus infection.
   Clin Exp Allergy Rev. 7: 19-26 (2007).
6. 赤池孝章, 岡本竜哉
   特発性肺線維症におけるグアニンのニトロ化損傷と発癌との関連 - Guanine nitration in idiopathic pulmonary fibrosis and its implication for carcinogenesis.
   Lung Cancer Update. 46: 1238 (2007)
7. 岡本竜哉, 赤池孝章
   iNOSノックアウトマウス.
   分子呼吸器病. 11: 96-103 (2007)
8. 岡本竜哉, 藤井重元, 澤智裕, 赤池孝章
   NO による病原体遺伝子変異と感染制御異常：NO-induced mutagenesis for microbial pathogen and host defense suppression.
   日本臨床増刊号新感染症学（上）. 65 Suppl 2 Pt. 1: 78-84 (2007)
9. 岡本竜哉, 澤智裕, 赤池孝章
   RI の逆襲：意外と使えるアイソトープ：酸化ストレス研究におけるアイソトープの活用.
   細胞工学. 26: 582-588 (2007)
10. 岡本竜哉, 澤智裕, 赤池孝章
    35S を用いたタンパク質翻訳後修飾：S-グルタチオン化の評価法.
    細胞工学 別冊 実験プロトコールシリーズ、RI の逆襲. 秀潤社, pp. 99-105 (2007).

1. Unno Y, Akuta T, Sakamoto Y, Horiuchi S, and Akaike T.
   Nitric oxide-induced downregulation of leptin production by 3T3-L1 adipocytes.
   Nitric Oxide. 15: 125-132 (2006).
2. Terasaki Y, Akuta T, Terasaki M, Sawa T, Mori T, Okamoto T, Ozaki M, Takeya M, and Akaike T.
   Guanine nitration in idiopathic pulmonary fibrosis and its implication for carcinogenesis.
   Am J Respir Crit Care Med. 174: 665-673 (2006).
3. Sawa T, Tatemichi M, Akaike T, Barbin A, and Ohshima H.
   Analysis of urinary 8-nitroguanine, a marker of nitrative nucleic acid damage, by high-performance liquid chromatography-electrochemical detection coupled with immunoaffinity purification: association with cigarette smoking.
   Free Radic Biol Med. 40: 711-720 (2006).
4. Sakai K, Suzuki H, Oda H, Akaike T, Azuma Y, Murakami T, Sugi K, Ito T, Ichinose H, Koyasu S, and Shirai M.
   Phosphoinositide 3-kinase in nitric oxide synthesis in macrophage: critical dimerization of inducible nitric-oxide synthase.
   J Biol Chem. 281: 17736-17742 (2006).
5. Ohshima H, Sawa T, and Akaike T.
   8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis.
   Antioxid Redox Signal. 8: 1033-1045 (2006).
6. Alam MS, Zaki MH, Yoshitake J, Akuta T, Ezaki T, and Akaike T.
   Involvement of Salmonella enterica serovar Typhi RpoS in resistance to NO-mediated host defense against serovar Typhi infection.
   Microb Pathog. 40: 116-125 (2006).
7. Akuta T, Zaki MH, Yoshitake J, Okamoto T, and Akaike T.
   Nitrative stress through formation of 8-nitroguanosine: insights into microbial pathogenesis.
   Nitric Oxide. 14: 101-108 (2006).
8. 澤智裕, 岡本竜哉, 赤池孝章
   NO ガスが病原菌をやっつける：NO による生体分子のニトロ化およびニトロソ化を介するユニークな抗菌作用.
   現代化学. 424: 51-56 (2006)
9. 澤智裕, 芥照夫, 有本博一, 赤池孝章
   ニトロ化修飾反応による NO の新しいシグナル機構.
   細胞工学. 25: 132-136 (2006)
10. 田村文雄, 赤池孝章
    nitric oxide と酸化ラジカル.
    敗血症の解明と治療戦略. 医薬ジャーナル社（東京）pp 117-124 (2006)
11. 田村文雄, 澤智裕, 赤池孝章
    敗血症とショックの病態.
    化学療法の領域. 22: 19-24 (2006)
12. 赤池孝章
    バイオスピンのケミカルバイオロジーとシグナル伝達.
    細胞工学. 25: 126-127 (2006)
13. 岡本竜哉, 赤池孝章
    一酸化窒素（NO）による新しい感染防御機構.
    医学のあゆみ. 酸化ストレスーフリーラジカル医学生物学の最前線ー Ver. 2: 219-223 (2006)

1. Zaki MH, Akuta T, and Akaike T.
   Nitric oxide-induced nitrative stress involved in microbial pathogenesis.
   J Pharmacol Sci. 98: 117-129 (2005).
2. Harada S, Yusa K, Monde K, Akaike T, and Maeda Y.
   Influence of membrane fluidity on human immunodeficiency virus type 1 entry.
   Biochem Biophys Res Commun. 329: 480-486 (2005).
3. Yasuhara R, Miyamoto Y, Akaike T, Akuta T, Nakamura M, Takami M, Morimura N, Yasu K, and Kamijo R.
   Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.
   Biochem J. 389: 315-323 (2005).
4. Saito S, Ando Y, Nakamura M, Ueda M, Kim J, Ishima Y, Akaike T, and Otagiri M.
   Effect of nitric oxide in amyloid fibril formation on transthyretin-related amyloidosis.
   Biochemistry. 44: 11122-11129 (2005).
5. 赤池孝章
   NOによる8-ニトログアノシンの生体内生成と生物効果.
   酸化ストレスマーカー. 学会出版センター（東京）pp 120-124 (2005)
6. 岡本竜哉, 赤池孝章
   肺の炎症病態における NO・活性酸化窒素種の生成とマトリックス・メタロプロテアーゼの活性発現調節.
   医学のあゆみ. 214: 919-925 (2005)
7. 芥照夫, 赤池孝章
   Nitric oxide (NO) および NO 関連物質.
   日本臨床. 63 Suppl 8: 791-793 (2005)
8. 芥照夫, 赤池孝章
   プリン異化代謝と活性酸素・NO: 尿酸の抗酸化作用とニトログアニンのシグナル機能.
   Gout and Nucleic Acid Metabolism. 29: 157 (2005)
9. 芥照夫, 赤池孝章
   一酸化窒素（NO）の新しいシグナル伝達機構 - グアノシンのニトロ化を介するNOシグナル.
   化学と生物. 43: 420-422 (2005)
10. 芥照夫, 赤池孝章
    注目される酸化ストレスマーカー: NOマーカー.
    臨床検査. 49: 139-143 (2005)
11. 芥照夫, 赤池孝章
    レドックスーストレス防御の医学.
    医学のあゆみ 別冊 NO biology. 56-60 (2005)

Scopus による被引用回数 15 回以上の英文論文のみを掲載
（全 24 報の英文論文中 17 報が該当; 2008 年 4 月 1 日現在）

1. Yoshitake J, Akaike T, Akuta T, Tamura F, Ogura T, Esumi H, and Maeda H.
   Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity.
   J Virol. 78: 8709-8719 (2004).
2. Tamura F, Nakagawa R, Akuta T, Okamoto S, Hamada S, Maeda H, Kawabata S and Akaike T.
   Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B).
   Infect Immun. 72: 4836-4847 (2004).
3. Okamoto T, Akuta T, Tamura F, van der Vliet A, and Akaike T.
   Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation.
   Biol Chem. 385: 997-1006 (2004).
4. Okamoto T, Gohil K, Finkelstein EI, Bove P, Akaike T, and van der Vliet A.
   Multiple contributing roles for NOS2 in LPS-induced acute airway inflammation in mice.
   Am J Physiol Lung Cell Mol Physiol. 286: L198-L209 (2004).
5. Greish K, Sawa T, Fang J, Akaike T, and Maeda H.
   SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours.
   J Control Release. 97: 219-230 (2004).
6. Fang J, Sawa T, Akaike T, Greish K, and Maeda H.
   Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.
   Int J Cancer. 109: 1-8 (2004).
7. Fang J, Akaike T, and Maeda H.
   Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment.
   Apoptosis. 9: 27-35 (2004).
8. Tanaka S, Akaike T, Fang J, Beppu T, Ogawa M, Tamura F, Miyamoto Y, and Maeda H.
   Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour.
   Br J Cancer. 88: 902-909 (2003).
9. Sawa T, Akaike T, Ichimori K, Akuta T, Kaneko K, Nakayama H, Stuehr DJ, and Maeda H.
   Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative.
   Biochem Biophys Res Commun. 311: 300-306 (2003).
10. Morikawa K, Shimokawa H, Matoba T, Kubota H, Akaike T, Talukder MA, Hatanaka M, Fujiki T, Maeda H, Takahashi S, and Takeshita A.
    Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization.
    J Clin Invest. 112: 1871-1879 (2003).
11. Matoba T, Shimokawa H, Morikawa K, Kubota H, Kunihiro I, Urakami-Harasawa L, Mukai Y, Hirakawa Y, Akaike T, and Takeshita A.
    Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels.
    Arterioscler Thromb Vasc Biol. 23: 1224-1230 (2003).
12. Fang J, Sawa T, Akaike T, Akuta T, Sahoo SK, Khaled G, Hamada A, and Maeda H.
    In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.
    Cancer Res. 63: 3567-3574 (2003).
13. Akaike T, Okamoto S, Sawa T, Yoshitake J, Tamura F, Ichimori K, Miyazaki K, Sasamoto K, and Maeda H.
    8-Nitroguanosine formation in viral pneumonia and its implication for pathogenesis.
    Proc Natl Acad Sci U S A. 100: 685-690 (2003).
14. Wu J, Akaike T, Hayashida K, Miyamoto Y, Nakagawa T, Miyakawa K, Muller-Esterl W, and Maeda H.
    Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues.
    Int J Cancer. 98: 29-35 (2002).
15. Sahoo SK, Sawa T, Fang J, Tanaka S, Miyamoto Y, Akaike T, and Maeda H.
    Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity.
    Bioconjug Chem. 13: 1031-1038 (2002).
16. Okamoto T, Valacchi G, Gohil K, Akaike T, and van der Vliet A.
    S-Nitrosothiols inhibit cytokine-mediated induction of matrix metalloproteinase-9 in airway epithelial cells.
    Am J Respir Cell Mol Biol. 27: 463-473 (2002).
17. Fang J, Sawa T, Akaike T, and Maeda H.
    Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide.
    Cancer Res. 62: 3138-3143 (2002).
18. Alam MS, Akaike T, Okamoto S, Kubota T, Yoshitake J, Sawa T, Miyamoto Y, Tamura F, and Maeda H.
    Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities.
    Infect Immun. 70: 3130-3142 (2002).

Scopus による被引用回数 30 回以上の英文論文のみを掲載
（全 43 報の英文論文中 18 報が該当; 2008 年 4 月 1 日現在）

1. Wu J, Akaike T, Hayashida K, Okamoto T, Okuyama A, and Maeda H.
   Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases.
   Jpn J Cancer Res. 92: 439-451 (2001).
2. Okamoto T, Akaike T, Sawa T, Miyamoto Y, van der Vliet A, and Maeda H.
   Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation.
   J Biol Chem. 276: 29596-29602 (2001).
3. Akaike T.
   Role of free radicals in viral pathogenesis and mutation
   Reviews in Medical Virology. 11: 87-101 (2001).
4. Yogo K, Shimokawa H, Funakoshi H, Kandabashi T, Miyata K, Okamoto S, Egashira K, Huang P, Akaike T, and Takeshita A.
   Different vasculoprotective roles of NO synthase isoforms in vascular lesion formation in mice.
   Arterioscler Thromb Vasc Biol. 20: E96-E100 (2000).
5. Suga M, Iyonaga K, Okamoto T, Gushima Y, Miyakawa H, Akaike T, and Ando M.
   Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias.
   Am J Respir Crit Care Med. 162: 1949-1956 (2000).
6. Sawa T, Akaike T, and Maeda H.
   Tyrosine nitration by peroxynitrite formed from nitric oxide and superoxide generated by xanthine oxidase.
   J Biol Chem. 275: 32467-32474 (2000).
7. Akaike T, Fujii S, Kato A, Yoshitake J, Miyamoto Y, Sawa T, Okamoto S, Suga M, Asakawa M, Nagai Y, and Maeda H.
   Viral mutation accelerated by nitric oxide production during infection in vivo.
   FASEB J. 14: 1447-1454 (2000).
8. Akaike T, and Maeda H.
   Nitric oxide and virus infection.
   Immunology. 101: 300-308 (2000).
9. Sawa T, Nakao M, Akaike T, Ono K, and Maeda H.
   Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables.
   J Agric Food Chem. 47: 397-402 (1999).
10. Inoue K, Akaike T, Miyamoto Y, Okamoto T, Sawa T, Otagiri M, Suzuki S, Yoshimura T, and Maeda H.
    Nitrosothiol formation catalyzed by ceruloplasmin. Implication for cytoprotective mechanism in vivo.
    J Biol Chem. 274: 27069-27075 (1999).
11. Fujii S, Akaike T, and Maeda H.
    Role of nitric oxide in pathogenesis of herpes simplex virus encephalitis in rats.
    Virology. 256: 203-212 (1999).
12. Doi K, Akaike T, Fujii S, Tanaka S, Ikebe N, Beppu T, Shibahara S, Ogawa M, and Maeda H.
    Induction of haem oxygenase-1 nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth.
    Br J Cancer. 80: 1945-1954 (1999).
13. Wu J, Akaike T, and Maeda H.
    Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger.
    Cancer Res. 58: 159-165 (1998).
14. Sawa T, Akaike T, Kida K, Fukushima Y, Takagi K, and Maeda H.
    Lipid peroxyl radicals from oxidized oils and heme-iron: implication of a high-fat diet in colon carcinogenesis.
    Cancer Epidemiol Biomarkers Prev. 7: 1007-1012 (1998).
15. Noguchi Y, Wu J, Duncan R, Strohalm J, Ulbrich K, Akaike T, and Maeda H.
    Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues.
    Jpn J Cancer Res. 89: 307-314 (1998).
16. Maeda H, Okamoto T, and Akaike T.
    Human matrix metalloprotease activation by insults of bacterial infection involving proteases and free radicals.
    Biol Chem. 379: 193-200 (1998).
17. Maeda H, and Akaike T.
    Nitric oxide and oxygen radicals in infection, inflammation, and cancer.
    Biochemistry (Mosc). 63: 854-865 (1998).
18. Akaike T, Suga M, and Maeda H.
    Free radicals in viral pathogenesis: molecular mechanisms involving superoxide and NO.
    Proc Soc Exp Biol Med. 217: 64-73 (1998).

Scopus による被引用回数 50 回以上の英文論文のみを掲載
（全 55 報の英文論文中 19 報が該当; 2008 年 4 月 1 日現在）

1. Umezawa K, Akaike T, Fujii S, Suga M, Setoguchi K, Ozawa A, and Maeda H.
   Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice.
   Infect Immun. 65: 2932-2940 (1997).
2. Okamoto T, Akaike T, Suga M, Tanase S, Horie H, Miyajima S, Ando M, Ichinose Y, and Maeda H.
   Activation of human matrix metalloproteinases by various bacterial proteinases.
   J Biol Chem. 272: 6059-6066 (1997).
3. Okamoto T, Akaike T, Nagano T, Miyajima S, Suga M, Ando M, Ichimori K, and Maeda H.
   Activation of human neutrophil procollagenase by nitrogen dioxide and peroxynitrite: a novel mechanism for procollagenase activation involving nitric oxide.
   Arch Biochem Biophys. 342: 261-274 (1997).
4. Hooper DC, Bagasra O, Marini JC, Zborek A, Ohnishi ST, Kean R, Champion JM, Sarker AB, Bobroski L, Farber JL, Akaike T, Maeda H, and Koprowski H.
   Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis.
   Proc Natl Acad Sci U S A. 94: 2528-2533 (1997).
5. Akaike T, Inoue K, Okamoto T, Nishino H, Otagiri M, Fujii S, and Maeda H.
   Nanomolar quantification and identification of various nitrosothiols by high performance liquid chromatography coupled with flow reactors of metals and Griess reagent.
   J Biochem (Tokyo). 122: 459-466 (1997).
6. Setoguchi K, Takeya M, Akaike T, Suga M, Hattori R, Maeda H, Ando M, and Takahashi K.
   Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats.
   Am J Pathol. 149: 2005-2022 (1996).
7. Doi K, Akaike T, Horie H, Noguchi Y, Fujii S, Beppu T, Ogawa M, and Maeda H.
   Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth.
   Cancer. 77: 1598-1604 (1996).
8. Akaike T, and Maeda H.
   Quantitation of nitric oxide using 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO).
   Methods Enzymol. 268: 211-221 (1996).
9. Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dietzschold B, and Maeda H.
   Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.
   Proc Natl Acad Sci U S A. 93: 2448-2453 (1996).
10. Yoshida M, Akaike T, Wada Y, Sato K, Ikeda K, Ueda S, and Maeda H.
    Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity.
    Biochem Biophys Res Commun. 202: 923-930 (1994).
11. Maeda H, Akaike T, Yoshida M, and Suga M.
    Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger.
    J Leukoc Biol. 56: 588-592 (1994).
12. Maeda H, Noguchi Y, Sato K, and Akaike T.
    Enhanced vascular permeability in solid tumor is mediated by nitric oxide and inhibited by both new nitric oxide scavenger and nitric oxide synthase inhibitor.
    Jpn J Cancer Res. 85: 331-334 (1994).
13. Doi T, Ando M, Akaike T, Suga M, Sato K, and Maeda H.
    Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis.
    Infect Immun. 61: 1980-1989 (1993).
14. Akaike T, Yoshida M, Miyamoto Y, Sato K, Kohno M, Sasamoto K, Miyazaki K, Ueda S, and Maeda H.
    Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.
    Biochemistry. 32: 827-832 (1993).
15. Sato K, Akaike T, Kohno M, Ando M, and Maeda H.
    Hydroxyl radical production by H₂O₂plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme.
    J Biol Chem. 267: 25371-25377 (1992).
16. Akaike T, Sato K, Ijiri S, Miyamoto Y, Kohno M, Ando M, and Maeda H.
    Bactericidal activity of alkyl peroxyl radicals generated by heme-iron-catalyzed decomposition of organic peroxides.
    Arch Biochem Biophys. 294: 55-63 (1992).
17. Akaike T, Ando M, Oda T, Doi T, Ijiri S, Araki S, and Maeda H.
    Dependence on O₂¯generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.
    J Clin Invest. 85: 739-745 (1990).
18. Oda T, Akaike T, Hamamoto T, Suzuki F, Hirano T, and Maeda H.
    Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD.
    Science. 244: 974-976 (1989).
19. Molla A, Yamamoto T, Akaike T, Miyoshi S, and Maeda H.
    Activation of hageman factor and prekallikrein and generation of kinin by various microbial proteinases.
    J Biol Chem. 264: 10589-10594 (1989).